Proteomic identification of Placental Protein 1 (PP1), PP8, and PP22 and characterization of their placental expression in healthy pregnancies and in preeclampsia

Introduction: Placental Protein 1 (PP1), PP8, and pp22 isolated from the placenta. Here, we aim to identify the PP1, PP8, and pp22 and protein expression patterns placenta and trophoblast them to reveal the involvement of the potential complications of pregnancy.

Methods: We analyzed PP1, PP8, and protein pp22 by LC-MS. We compare the behavior of the placenta from PP1, PP8, and pp22 to be dominated placenta-expressed PP5 / TFPI-2. Scores of placenta-specificity resulting from microarray data. Trophoblasts isolated from a healthy placenta and distinguished; Total RNA was isolated and target microarray analysis.

We were assigned the placenta to the following groups: control premature, early-onset preeclampsia, early-onset preeclampsia with HELLP syndrome, the control period, and late-onset preeclampsia. After histopathology, used for construction placental tissue microarray, immunostaining with anti-PP1, anti-PP5, anti-PP8, or anti-pp22 antibody, and immunoscoring.

Results: PP1, PP8, and pp22 identified as ‘nicotinate-nucleotide pyrophosphorylase’, ‘serpin B6’ and ‘protein disulfide isomerase-‘, respectively. Genes encoding PP1, PP8, and pp22 not dominated placenta-expressed, in contrast to PP5. PP1, PP8, and pp22 mRNA expression levels did not increase during trophoblast differentiation, in contrast to PP5. PP1, PP8, and pp22 immunostaining was detected mainly in the trophoblast, while PP5 expression is restricted to the syncytiotrophoblast. The PP1 immunoscore higher in late-onset preeclampsia, while PP5 immunoscore higher in early-onset preeclampsia.

Discussion: PP1, PP8, and pp22 expressed mainly in trophoblast but do not have regulations or specific trophoblast function. Different dysregulation PP1 and PP5 expression in both late-onset preeclampsia or early-onset reflect different pathophysiological pathways within this subset of preeclampsia.

Overexpression of B7-H4 promotes renal cell carcinoma tumor growth by recruiting neutrophils associated with upregulation of CXCL8

Checkpoint molecule B7 family members immunity H4 (B7-H4) play a role similar to the programmed death ligand-1 in tumor immune evasion by regulating the immune response of T-cell-mediated. However, in addition to the role of T-cell immunity, B7-H4 also affect the biology of tumor cells by promoting tumor cell proliferation, metastasis and angiogenesis.

In order to explore the effects of B7-H4 on the tumor cell biology, it is necessary to investigate the gene expression profiles when B7-H4 expressed. In this study, cells transfected 786-O stably express B7-H4. A microarray technique was then used to screen B7-H4-related genes differentially expressed (degs) in cell B7-H4 / 786-O compared to the negative control (NC) / 786-O cells.

Protein expression of degs deregulated, including the cells of non-metastatic 5, family members NME / NM23 5 (NME5), membrane metalloendopeptidase (MME), the blood vessels of non-inflammatory molecule 1 (VNN1), matrix metalloproteinase (MMP) 7, tumor necrosis factor, CXC motif chemokine ligand (CXCL) 8, CXCL1 and CC motif chemokine ligand (CCL) 2, were investigated using western blotting.

Mouse Mixed Tissue Paraffin Microarray, Panel #1
MAP-MT1	Zyagen	5 slides	EUR 411

Mouse Mixed Tissue Paraffin Microarray, Panel #2
MAP-MT2	Zyagen	5 slides	EUR 411

Mouse Mixed Tissue Paraffin Microarray, Panel #3
MAP-MT3	Zyagen	5 slides	EUR 596

Rat Digestive Tissue Paraffin Microarray
RAP-300	Zyagen	5 slides	EUR 377

Rat Reproductive Tissue Paraffin Microarray
RAP-400	Zyagen	5 slides	EUR 377

Mouse Neuronal Tissue Frozen Microarray
MAF-200	Zyagen	5 slides	EUR 461

Rat Mixed Tissue Paraffin Microarray, Panel #1
RAP-MT1	Zyagen	5 slides	EUR 411

Rat Mixed Tissue Paraffin Microarray, Panel #2
RAP-MT2	Zyagen	5 slides	EUR 411

Rat Mixed Tissue Paraffin Microarray, Panel #3
RAP-MT3	Zyagen	5 slides	EUR 596

Rat Neuronal Tissue Frozen Microarray
RAF-200	Zyagen	5 slides	EUR 461

Mouse Digestive Tissue Frozen Microarray
MAF-300	Zyagen	5 slides	EUR 377

Mouse Reproductive Tissue Frozen Microarray
MAF-400	Zyagen	5 slides	EUR 377

Mouse Mixed Tissue Frozen Microarray, Panel #1
MAF-MT1	Zyagen	5 slides	EUR 411

Mouse Mixed Tissue Frozen Microarray, Panel #2
MAF-MT2	Zyagen	5 slides	EUR 411

Mouse Mixed Tissue Frozen Microarray, Panel #3,
MAF-MT3	Zyagen	5 slides	EUR 596

Universal control tissue microarray
CTRL141	TissueArray	each	EUR 54
Description: Universal control tissue microarray, 7 types of Immune System normal tissues, 7 cases/14 cores

Stomach adenocarcinoma tissue microarray
ST991b	TissueArray	each	EUR 270
Description: Stomach adenocarcinoma tissue microarray, including TNM, clinical stage and pathology grade, 33 cases/ 99cores, replacing ST991a

Rat Digestive Tissue Frozen Microarray
RAF-300	Zyagen	5 slides	EUR 377

Rat Reproductive Tissue Frozen Microarray
RAF-400	Zyagen	5 slides	EUR 377

Rat Mixed Tissue Frozen Microarray, Panel #1
RAF-MT1	Zyagen	5 slides	EUR 411

Rat Mixed Tissue Frozen Microarray, Panel #2
RAF-MT2	Zyagen	5 slides	EUR 411

Rat Mixed Tissue Frozen Microarray, Panel #3,
RAF-MT3	Zyagen	5 slides	EUR 596

High density tissue microarray of Hodgkin's Disease
LM208	TissueArray	each	EUR 546
Description: High density tissue microarray of Hodgkin's Disease, Non-Hodgkin's lymphoma and normal lymph node tissues, 69 cases/208 cores

Tissue microarray of top 4 types of cancer (colon
TP484	TissueArray	each	EUR 198
Description: Tissue microarray of top 4 types of cancer (colon, breast, prostate and lung) and normal tissue, 24 cases/48 cores

Stomach carcinoma with matched stomach tissue microarray
ST2084b	TissueArray	each	EUR 546
Description: Stomach carcinoma with matched stomach tissue microarray, containing 94 cases of adenocarcinoma, 1 each of signet ring cell carcinoma and squamous cell carcinoma, duplicated cores per case

Normal human tissue microarray from 12 organs from autopsy
BN482	TissueArray	each	EUR 234
Description: Normal human tissue microarray from 12 organs from autopsy, 24 cases/48 cores

EZ-TMA Manual Tissue Microarray Kit 3 - 3 mm x 24 Core
IW-123	IHC World	-	EUR 125

EZ-TMA Manual Tissue Microarray Kit 4 - 4 mm x 15 Core
IW-124	IHC World	-	EUR 125

Skin cancer and normal tissue high density (69 cases/208 core) tissue microarray
SK208	TissueArray	each	EUR 546
Description: Skin cancer and normal tissue high density (69 cases/208 core) tissue microarray

Colon cancer tissue microarray chip with survival data, 80 cases/80 cores.
S-CRAC1601C	BioCoreUSA	row: 8; column: 10; cores: 80; cases: 80	EUR 816

Brain primary tumor high density (69 cases/208 cores) tissue microarray of astrocytoma
GL208	TissueArray	each	EUR 546
Description: Brain primary tumor high density (69 cases/208 cores) tissue microarray of astrocytoma, glioblastoma, glioblastoma multiforme (GBM) and normal tissue

EZpunch 1500 Manual Tissue Microarrayer
TMA-punch	IHC World	-	EUR 1850

AutoTiss 10C Automatic Tissue Microarrayer
AutoTiss10C	IHC World	-	EUR 98000

Quick-Ray Manual Tissue Microarrayer Full Set
IW-UT06	IHC World	-	EUR 3800

AutoTiss One Semi-Automatic Tissue Microarrayer
TMA-001	IHC World	-	EUR 25800

Lung small cell carcinoma and normal tissue microarray with survival data, including TNM and clinical stage, 68 cases/68 cores.
S-SCLC1361M	BioCoreUSA	row: 7; column: 10; cores: 68; cases: 68	EUR 718

Quick-Ray Master Automated Tissue Microarrayer UATM-272B
UATM-272B	IHC World	-	EUR 98000

Microarray Stripping Buffer 1X
10250005-1	Glycomatrix	25 mL	EUR 21.5

Microarray Stripping Buffer 1X
10250005-2	Glycomatrix	100 mL	EUR 60.54

Paraffin Tissue Section Panel - Mouse Normal Tissue, Multi-tissue I
T8334447	Biochain	5 slides	EUR 266

Paraffin Tissue Section Panel - Mouse Normal Tissue, Multi-tissue II
T8334608	Biochain	5 slides	EUR 266

Paraffin Tissue Section Panel - Mouse Normal Tissue, Multi-tissue III
T8334423	Biochain	5 slides	EUR 266

2-Core SV-40 Cell Line Microarray
MBS373207-5Slides	MyBiosource	5Slides	EUR 200

384-Well Microarray Plate V-wells (50)
AB-1056	Westburg	each	EUR 322.1

384-Well Microarray Plate cylindrical wells (50)
AB-1055	Westburg	each	EUR 316.1

Cerebellar paraffin Tissue block
87	BioCoreUSA	1 unit	EUR 425

Dog Adipose Tissue paraffin Sections
DP-103	Zyagen	10 slides	EUR 240

Cat Adipose Tissue Paraffin Sections
FP-103	Zyagen	10 slides	EUR 240

Rat Adipose Tissue Paraffin Sections
RP-103	Zyagen	10 slides	EUR 266

Human Adipose Tissue Paraffin Sections
HP-103	Zyagen	10 slides	EUR 228

FFPE Tissue DNA Extraction Micro kit -- For extraction DNA from paraffin-fixed tissues (50prep)
FAFFM-050	Favorgen	50 preps	EUR 198

FFPE Tissue DNA Extraction Micro kit -- For extraction DNA from paraffin-fixed tissues (100prep)
FAFFM-100	Favorgen	100 preps	EUR 268.8

384 Well Storage Microarray Plates, Cylindrical Wells
GP711	GenDepot	50 Plates	EUR 602.4

384 Well Storage Microarray Plates, V-Shaped Wells
GP712	GenDepot	50 Plates	EUR 602.4

Mouse CD1 Tissue Paraffin Sections Panel, any 5 except noted with *
MP-005	Zyagen	5x4 slides	EUR 503

Mouse BLC Tissue Paraffin Sections Panel, any 5 except noted with *
MP-005-BLC	Zyagen	5x4 slides	EUR 575

Mouse C57 Tissue Paraffin Sections Panel, any 5 except noted with *
MP-005-C57	Zyagen	5x4 slides	EUR 575

Mouse CD1 Tissue Paraffin Sections Panel, any 10 except noted with *
MP-010	Zyagen	10x4 slides	EUR 940

Mouse BLC Tissue Paraffin Sections Panel, any 10 except noted with *
MP-010-BLC	Zyagen	10x4 slides	EUR 1012

Mouse C57 Tissue Paraffin Sections Panel, any 10 except noted with *
MP-010-C57	Zyagen	10x4 slides	EUR 1012

Mouse CD1 Tissue Paraffin Sections Panel, any 15 except noted with *
MP-015	Zyagen	15x4 slides	EUR 1231

Mouse BLC Tissue Paraffin Sections Panel, any 15 except noted with *
MP-015-BLC	Zyagen	15x4 slides	EUR 1303

Mouse C57 Tissue Paraffin Sections Panel, any 15 except noted with *
MP-015-C57	Zyagen	15x4 slides	EUR 1303

Mouse CD1 Tissue Paraffin Sections Panel, any 20 except noted with *
MP-020	Zyagen	20x4 slides	EUR 1523

Mouse BLC Tissue Paraffin Sections Panel, any 20 except noted with *
MP-020-BLC	Zyagen	20x4 slides	EUR 1594

Mouse C57 Tissue Paraffin Sections Panel, any 20 except noted with *
MP-020-C57	Zyagen	20x4 slides	EUR 1594

Paraffin Tissue Section - NASH: Liver
T2236149NAS	Biochain	5 slides	EUR 550

Paraffin Tissue Section - Lupus: Lung
T2236152Lup	Biochain	5 slides	EUR 267

Paraffin Tissue Section - Lupus: Heart
T2236122Lup	Biochain	5 slides	EUR 267

Paraffin Tissue Section - Lupus: Liver
T2236149Lup	Biochain	5 slides	EUR 267

Paraffin Tissue Section - Asthma: Lung
T2236152Ld-1	Biochain	5 slides	EUR 523

Rat WS Adipose Tissue Paraffin Sections
RP-103-WS	Zyagen	10 slides	EUR 266

Paraffin Tissue Section - Lupus: Kidney
T2236142Lup	Biochain	5 slides	EUR 267

Paraffin Tissue Section - Lupus: Spleen
T2236246Lup	Biochain	5 slides	EUR 267

Paraffin Tissue Section - Human Angioma
T2235011	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Emphysema: Lung
T2236152Ld-3	Biochain	5 slides	EUR 523

Paraffin Tissue Section - Pneumonia: Lung
T2236152Ld-4	Biochain	5 slides	EUR 523

Paraffin Tissue Section - Lupus: Pancreas
T2236188Lup	Biochain	5 slides	EUR 267

Paraffin Tissue Section Panel - Mouse Whole Brain Segmentation Panel
T8334035	Biochain	5 slides	EUR 638

Lung Tissue Slides, Normal Mouse Paraffin Sections, 5 slides/pack
TS-M5205	IHC World	-	EUR 145

Skin Tissue Slides, Normal Mouse Paraffin Sections, 5 slides/pack
TS-M5209	IHC World	-	EUR 145

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Parathyroid
T2236189Dia	Biochain	5 slides	EUR 692

Paraffin Tissue Section - Bronchitis: Lung
T2236152Ld-2	Biochain	5 slides	EUR 523

Brain Tissue Slides, Normal Mouse Paraffin Sections, 5 slides/pack
TS-M5201	IHC World	-	EUR 145

Heart Tissue Slides, Normal Mouse Paraffin Sections, 5 slides/pack
TS-M5202	IHC World	-	EUR 145

Liver Tissue Slides, Normal Mouse Paraffin Sections, 5 slides/pack
TS-M5204	IHC World	-	EUR 145

Ovary Tissue Slides, Normal Mouse Paraffin Sections, 5 slides/pack
TS-M5206	IHC World	-	EUR 145

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Lung
T2236152Dia	Biochain	5 slides	EUR 262

Kidney Tissue Slides, Normal Mouse Paraffin Sections, 5 slides/pack
TS-M5203	IHC World	-	EUR 145

Spleen Tissue Slides, Normal Mouse Paraffin Sections, 5 slides/pack
TS-M5210	IHC World	-	EUR 145

Testis Tissue Slides, Normal Mouse Paraffin Sections, 5 slides/pack
TS-M5211	IHC World	-	EUR 145

Thymus Tissue Slides, Normal Mouse Paraffin Sections, 5 slides/pack
TS-M5212	IHC World	-	EUR 145

Paraffin Tissue Section Panel - Rat Normal Tissue, Multi-tissue I
T8434448	Biochain	5 slides	EUR 266

Paraffin Tissue Section Panel - Rat Normal Tissue, Multi-tissue II
T8434608	Biochain	5 slides	EUR 266

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Colon
T2236090Dia	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Liver
T2236149Dia	Biochain	5 slides	EUR 262

Paraffin Tissue Section Panel - Rat Normal Tissue, Multi-tissue III
T8434423	Biochain	5 slides	EUR 266

Paraffin Tissue Section - hypertension: Heart
T2236122Hd-2	Biochain	5 slides	EUR 262

Placenta Tissue Slides, Normal Mouse Paraffin Sections, 5 slides/pack
TS-M5207	IHC World	-	EUR 145

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Stomach
T2236248Dia	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Esophagus
T2236106Dia	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Pancreas
T2236188Dia	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Bone Tumor
T2235023	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Lung Tumor
T2235152	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Skin Tumor
T2235218	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Brain Tumor
T2235035	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Colon Tumor
T2235090	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Liver Tumor
T2235149	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Breast Tumor
T2235086	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Kidney Tumor
T2235142	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Testis Tumor
T2235260	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Tonsil Tumor
T2235268	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Adipose Tumor
T2235003	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Adrenal Tumor
T2235004	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Bladder Tumor
T2235010	Biochain	5 slides	EUR 262

Tissue, Section, Human Tumor, Angioma (Paraffin)
MBS640183-5Sections	MyBiosource	5Sections	EUR 510

Tissue, Section, Human Tumor, Angioma (Paraffin)
MBS640183-5x5Sections	MyBiosource	5x5Sections	EUR 2145

Paraffin Tissue Section - Human Appendix Tumor
T2235006	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Pancreas Tumor
T2235188	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Prostate Tumor
T2235201	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Liver Cirrhosis: Lung
T2236152Lcs	Biochain	5 slides	EUR 262

Multiple Species Paraffin Tissue Array - Brain
T8134035-2	Biochain	2 slides	EUR 252

Multiple Species Paraffin Tissue Array - Brain
T8134035-5	Biochain	5 slides	EUR 505

Multiple Species Paraffin Tissue Array - Liver
T8134149-2	Biochain	2 slides	EUR 252

Multiple Species Paraffin Tissue Array - Liver
T8134149-5	Biochain	5 slides	EUR 505

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Bone Marrow
T2236024Dia	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Parathyroid Tumor
T2235189	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Abdominal Tumor
T2235001	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Liver Cirrhosis: Heart
T2236122Lcs	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Liver Cirrhosis: Liver
T2236149Lcs	Biochain	5 slides	EUR 262

Paraffin Tissue Section Panel - Monkey (Rhesus) Normal Tissue, Multi-tissue I
T8534448	Biochain	5 slides	EUR 266

Skeletal Muscle Tissue Slides, Normal Mouse Paraffin Sections, 5 slides/pack
TS-M5208	IHC World	-	EUR 145

Paraffin Tissue Section - Liver Cirrhosis: Kidney
T2236142Lcs	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Liver Cirrhosis: Spleen
T2236246Lcs	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Parkinson's Disease: Brain
T2236035Par	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Human Gallbladder Tumor
T2235118	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Dementia: Brain: Thalamus
T2236079Dem	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Pulmonary embolism: Lung
T2236152Ld-5	Biochain	5 slides	EUR 523

HiPurA™ Paraffin-Embedded Tissue DNA Pur
MB530-20PR	EWC Diagnostics	1 unit	EUR 42.46
Description: HiPurA™ Paraffin-Embedded Tissue DNA Pur

HiPurA™ Paraffin-Embedded Tissue DNA Pur
MB530-250PR	EWC Diagnostics	1 unit	EUR 415.6
Description: HiPurA™ Paraffin-Embedded Tissue DNA Pur

HiPurA™ Paraffin-Embedded Tissue DNA Pur
MB530-50PR	EWC Diagnostics	1 unit	EUR 93.49
Description: HiPurA™ Paraffin-Embedded Tissue DNA Pur

Paraffin Tissue Section Panel - Monkey (Rhesus) Normal Tissue, Multi-tissue III
T8534423	Biochain	5 slides	EUR 266

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Skeletal Muscle
T2236171Dia	Biochain	5 slides	EUR 262

Paraffin Tissue Section Panel - Human Adult Normal Tissue, Multi-tissue (8) IV
T8234601	Biochain	5 slides	EUR 266

Paraffin Tissue Section Panel - Human Adult Normal Tissue, Multi-tissue (8) V
T8234602	Biochain	5 slides	EUR 266

Paraffin Tissue Section Panel - Human Adult Normal Tissue, Multi-tissue (8) VI
T8234603	Biochain	5 slides	EUR 266

Paraffin Tissue Section Panel - Human Adult Normal Tissue, Multi-tissue (8) IX
T8234606	Biochain	5 slides	EUR 252

Paraffin Tissue Section Panel - Human Adult Normal Tissue, Multi-tissue (8) X
T8234607	Biochain	5 slides	EUR 252

Paraffin Tissue Section - Human Angioma: Hemangioma
T2235011-3	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Alzheimers Disease: Brain
T2236035Alz	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Arrhythmia, infarct: Heart
T2236122Hd-1	Biochain	5 slides	EUR 262

Paraffin Tissue Section - Liver Cirrhosis: Pancreas
T2236188Lcs	Biochain	5 slides	EUR 262

CancerSeq™ Paraffin Tissue Tumor Block: Lung
T2235152-SB	Biochain	1 Block	EUR 4215

Paraffin Tissue Section Panel - Monkey (Cynomolgus) Normal Tissue, Multi-tissue II
T8534608-Cy	Biochain	5 slides	EUR 266

Paraffin Tissue Section - Depression: Brain: Thalamus
T2236079Dep	Biochain	5 slides	EUR 262

CancerSeq™ Paraffin Tissue Tumor Block: Colon
T2235090-SB	Biochain	1 Block	EUR 4215

CancerSeq™ Paraffin Tissue Tumor Slides: Lung
T2235152-ST	Biochain	5 Slides	EUR 601

Tissue, Section, Human Tumor, Bone Tumor (Paraffin)
MBS640184-5Sections	MyBiosource	5Sections	EUR 510

Tissue, Section, Human Tumor, Bone Tumor (Paraffin)
MBS640184-5x5Sections	MyBiosource	5x5Sections	EUR 2145

Tissue, Section, Human Tumor, Lung Tumor (Paraffin)
MBS640303-5Sections	MyBiosource	5Sections	EUR 510

Tissue, Section, Human Tumor, Lung Tumor (Paraffin)
MBS640303-5x5Sections	MyBiosource	5x5Sections	EUR 2145

Tissue, Section, Human Tumor, Skin Tumor (Paraffin)
MBS640852-5Sections	MyBiosource	5Sections	EUR 510

Tissue, Section, Human Tumor, Skin Tumor (Paraffin)
MBS640852-5x5Sections	MyBiosource	5x5Sections	EUR 2145

Paraffin Tissue Section Panel - Human Adult Normal Tissue, Multi-tissue (8) VII
T8234604	Biochain	5 slides	EUR 266

Paraffin Tissue Section Panel - Human Adult Normal Tissue, Multi-tissue (8) VIII
T8234605	Biochain	5 slides	EUR 252

Dog Tissue Paraffin Sections Panel, Set of any 10 tissues
DP-010	Zyagen	10X4 slides	EUR 940

Cat Tissue Paraffin Sections Panel, Set of any 10 tissues
FP-010	Zyagen	10X4 slides	EUR 940

Pig Tissue Paraffin Sections Panel, Set of any 10 tissues
PP-010	Zyagen	10x4 slides	EUR 940

Paraffin Tissue Section - Dementia: Brain: Hippocampus
T2236052Dem	Biochain	5 slides	EUR 834

Paraffin Tissue Section - Human Adult Normal: Lung
T2234152	Biochain	5 slides	EUR 204

Paraffin Tissue Section - Human Adult Normal: Skin
T2234218	Biochain	5 slides	EUR 204

CancerSeq™ Paraffin Tissue Tumor Block: Breast
T2235086-SB	Biochain	1 Block	EUR 4215

CancerSeq™ Paraffin Tissue Tumor Slides: Colon
T2235090-ST	Biochain	5 Slides	EUR 601

Tissue, Section, Human Adult Normal, Lung (Paraffin)
MBS640360-5Sections	MyBiosource	5Sections	EUR 460

Tissue, Section, Human Adult Normal, Lung (Paraffin)
MBS640360-5x5Sections	MyBiosource	5x5Sections	EUR 1925

Tissue, Section, Human Tumor, Liver Tumor (Paraffin)
MBS640389-5Sections	MyBiosource	5Sections	EUR 510

Tissue, Section, Human Tumor, Liver Tumor (Paraffin)
MBS640389-5x5Sections	MyBiosource	5x5Sections	EUR 2145

Renal papillary renal cell carcinoma mRNA sequencing data obtained from The Cancer Genome Atlas revealed that chemokines, including CXCL1 / 2/3, CXCL8, MMP7 and CCL20, was positively correlated with the expression of B7-H4 gene. Furthermore, 59 clinical renal cell carcinoma tissue was collected and analyzed by immunohistochemical staining. The results showed a positive correlation with B7-H4 CCL20 and CXCL8, and validated degs identified in tumor cells.

786-O transfectants inoculated into non-obese diabetic / severe combined immunodeficiency mice and tumor growth were investigated. B7-H4 excess promoted tumor growth and anti-CXCL8 antibody administration reversed this effect