Proteomic identification of Placental Protein 1 (PP1), PP8, and PP22 and characterization of their placental expression in healthy pregnancies and in preeclampsia

Introduction: Placental Protein 1 (PP1), PP8, and pp22 isolated from the placenta. Here, we aim to identify the PP1, PP8, and pp22 and protein expression patterns placenta and trophoblast them to reveal the involvement of the potential complications of pregnancy.

Methods: We analyzed PP1, PP8, and protein pp22 by LC-MS. We compare the behavior of the placenta from PP1, PP8, and pp22 to be dominated placenta-expressed PP5 / TFPI-2. Scores of placenta-specificity resulting from microarray data. Trophoblasts isolated from a healthy placenta and distinguished; Total RNA was isolated and target microarray analysis.

We were assigned the placenta to the following groups: control premature, early-onset preeclampsia, early-onset preeclampsia with HELLP syndrome, the control period, and late-onset preeclampsia. After histopathology, used for construction placental tissue microarray, immunostaining with anti-PP1, anti-PP5, anti-PP8, or anti-pp22 antibody, and immunoscoring.

Results: PP1, PP8, and pp22 identified as ‘nicotinate-nucleotide pyrophosphorylase’, ‘serpin B6’ and ‘protein disulfide isomerase-‘, respectively. Genes encoding PP1, PP8, and pp22 not dominated placenta-expressed, in contrast to PP5. PP1, PP8, and pp22 mRNA expression levels did not increase during trophoblast differentiation, in contrast to PP5. PP1, PP8, and pp22 immunostaining was detected mainly in the trophoblast, while PP5 expression is restricted to the syncytiotrophoblast. The PP1 immunoscore higher in late-onset preeclampsia, while PP5 immunoscore higher in early-onset preeclampsia.

Discussion: PP1, PP8, and pp22 expressed mainly in trophoblast but do not have regulations or specific trophoblast function. Different dysregulation PP1 and PP5 expression in both late-onset preeclampsia or early-onset reflect different pathophysiological pathways within this subset of preeclampsia.

Overexpression of B7-H4 promotes renal cell carcinoma tumor growth by recruiting neutrophils associated with upregulation of CXCL8

Checkpoint molecule B7 family members immunity H4 (B7-H4) play a role similar to the programmed death ligand-1 in tumor immune evasion by regulating the immune response of T-cell-mediated. However, in addition to the role of T-cell immunity, B7-H4 also affect the biology of tumor cells by promoting tumor cell proliferation, metastasis and angiogenesis.

In order to explore the effects of B7-H4 on the tumor cell biology, it is necessary to investigate the gene expression profiles when B7-H4 expressed. In this study, cells transfected 786-O stably express B7-H4. A microarray technique was then used to screen B7-H4-related genes differentially expressed (degs) in cell B7-H4 / 786-O compared to the negative control (NC) / 786-O cells.

Protein expression of degs deregulated, including the cells of non-metastatic 5, family members NME / NM23 5 (NME5), membrane metalloendopeptidase (MME), the blood vessels of non-inflammatory molecule 1 (VNN1), matrix metalloproteinase (MMP) 7, tumor necrosis factor, CXC motif chemokine ligand (CXCL) 8, CXCL1 and CC motif chemokine ligand (CCL) 2, were investigated using western blotting.

Stomach carcinoma with matched stomach tissue microarray
ST2084b	TissueArray	each	EUR 546
Description: Stomach carcinoma with matched stomach tissue microarray, containing 94 cases of adenocarcinoma, 1 each of signet ring cell carcinoma and squamous cell carcinoma, duplicated cores per case

Normal human tissue microarray from 12 organs from autopsy
BN482	TissueArray	each	EUR 234
Description: Normal human tissue microarray from 12 organs from autopsy, 24 cases/48 cores

Skin cancer and normal tissue high density (69 cases/208 core) tissue microarray
SK208	TissueArray	each	EUR 546
Description: Skin cancer and normal tissue high density (69 cases/208 core) tissue microarray

Brain primary tumor high density (69 cases/208 cores) tissue microarray of astrocytoma
GL208	TissueArray	each	EUR 546
Description: Brain primary tumor high density (69 cases/208 cores) tissue microarray of astrocytoma, glioblastoma, glioblastoma multiforme (GBM) and normal tissue

Paraffin Tissue Section Panel - Mouse Normal Tissue, Multi-tissue I
T8334447	Biochain	5 slides	EUR 242

Paraffin Tissue Section Panel - Mouse Normal Tissue, Multi-tissue II
T8334608	Biochain	5 slides	EUR 242

Paraffin Tissue Section Panel - Mouse Normal Tissue, Multi-tissue III
T8334423	Biochain	5 slides	EUR 242

Paraffin Tissue Section - NASH: Liver
T2236149NAS	Biochain	5 slides	EUR 524

Paraffin Tissue Section - Lupus: Lung
T2236152Lup	Biochain	5 slides	EUR 243

Paraffin Tissue Section - Lupus: Heart
T2236122Lup	Biochain	5 slides	EUR 243

Paraffin Tissue Section - Lupus: Liver
T2236149Lup	Biochain	5 slides	EUR 243

Paraffin Tissue Section - Asthma: Lung
T2236152Ld-1	Biochain	5 slides	EUR 475

Paraffin Tissue Section - Lupus: Kidney
T2236142Lup	Biochain	5 slides	EUR 243

Paraffin Tissue Section - Lupus: Spleen
T2236246Lup	Biochain	5 slides	EUR 243

Paraffin Tissue Section - Human Angioma
T2235011	Biochain	5 slides	EUR 238

FFPE Tissue DNA Extraction Micro kit -- For extraction DNA from paraffin-fixed tissues (50prep)
FAFFM-050	Favorgen	50 preps	EUR 198

FFPE Tissue DNA Extraction Micro kit -- For extraction DNA from paraffin-fixed tissues (100prep)
FAFFM-100	Favorgen	100 preps	EUR 268.8

Paraffin Tissue Section - Emphysema: Lung
T2236152Ld-3	Biochain	5 slides	EUR 475

Paraffin Tissue Section - Pneumonia: Lung
T2236152Ld-4	Biochain	5 slides	EUR 475

Paraffin Tissue Section - Lupus: Pancreas
T2236188Lup	Biochain	5 slides	EUR 243

Paraffin Tissue Section - Bronchitis: Lung
T2236152Ld-2	Biochain	5 slides	EUR 475

384 Well Storage Microarray Plates, V-Shaped Wells
GP712	GenDepot	50 Plates	EUR 602.4

384 Well Storage Microarray Plates, Cylindrical Wells
GP711	GenDepot	50 Plates	EUR 602.4

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Parathyroid
T2236189Dia	Biochain	5 slides	EUR 629

Paraffin Tissue Section - hypertension: Heart
T2236122Hd-2	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Lung
T2236152Dia	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Bone Tumor
T2235023	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Lung Tumor
T2235152	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Skin Tumor
T2235218	Biochain	5 slides	EUR 238

Paraffin Tissue Section Panel - Rat Normal Tissue, Multi-tissue I
T8434448	Biochain	5 slides	EUR 242

Paraffin Tissue Section Panel - Rat Normal Tissue, Multi-tissue II
T8434608	Biochain	5 slides	EUR 242

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Colon
T2236090Dia	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Liver
T2236149Dia	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Brain Tumor
T2235035	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Colon Tumor
T2235090	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Liver Tumor
T2235149	Biochain	5 slides	EUR 238

Paraffin Tissue Section Panel - Rat Normal Tissue, Multi-tissue III
T8434423	Biochain	5 slides	EUR 242

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Stomach
T2236248Dia	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Breast Tumor
T2235086	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Kidney Tumor
T2235142	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Testis Tumor
T2235260	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Tonsil Tumor
T2235268	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Esophagus
T2236106Dia	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Pancreas
T2236188Dia	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Adipose Tumor
T2235003	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Adrenal Tumor
T2235004	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Bladder Tumor
T2235010	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Appendix Tumor
T2235006	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Pancreas Tumor
T2235188	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Prostate Tumor
T2235201	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Liver Cirrhosis: Lung
T2236152Lcs	Biochain	5 slides	EUR 238

Multiple Species Paraffin Tissue Array - Brain
T8134035-2	Biochain	2 slides	EUR 229

Multiple Species Paraffin Tissue Array - Brain
T8134035-5	Biochain	5 slides	EUR 459

Multiple Species Paraffin Tissue Array - Liver
T8134149-2	Biochain	2 slides	EUR 229

Multiple Species Paraffin Tissue Array - Liver
T8134149-5	Biochain	5 slides	EUR 459

Paraffin Tissue Section - Human Parathyroid Tumor
T2235189	Biochain	5 slides	EUR 238

Paraffin Tissue Section Panel - Mouse Whole Brain Segmentation Panel
T8334035	Biochain	5 slides	EUR 580

Paraffin Tissue Section - Human Abdominal Tumor
T2235001	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Liver Cirrhosis: Heart
T2236122Lcs	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Liver Cirrhosis: Liver
T2236149Lcs	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Liver Cirrhosis: Kidney
T2236142Lcs	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Liver Cirrhosis: Spleen
T2236246Lcs	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Parkinson's Disease: Brain
T2236035Par	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Bone Marrow
T2236024Dia	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Gallbladder Tumor
T2235118	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Dementia: Brain: Thalamus
T2236079Dem	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Pulmonary embolism: Lung
T2236152Ld-5	Biochain	5 slides	EUR 475

CancerSeq™ Paraffin Tissue Tumor Block: Lung
T2235152-SB	Biochain	1 Block	EUR 4014

Paraffin Tissue Section - Human Angioma: Hemangioma
T2235011-3	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain
T2236035Alz	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Arrhythmia, infarct: Heart
T2236122Hd-1	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Liver Cirrhosis: Pancreas
T2236188Lcs	Biochain	5 slides	EUR 238

CancerSeq™ Paraffin Tissue Tumor Block: Colon
T2235090-SB	Biochain	1 Block	EUR 4014

CancerSeq™ Paraffin Tissue Tumor Slides: Lung
T2235152-ST	Biochain	5 Slides	EUR 572

Paraffin Tissue Section Panel - Monkey (Rhesus) Normal Tissue, Multi-tissue I
T8534448	Biochain	5 slides	EUR 242

Paraffin Tissue Section - Depression: Brain: Thalamus
T2236079Dep	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Adult Normal: Lung
T2234152	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Skin
T2234218	Biochain	5 slides	EUR 185

CancerSeq™ Paraffin Tissue Tumor Block: Breast
T2235086-SB	Biochain	1 Block	EUR 4014

CancerSeq™ Paraffin Tissue Tumor Slides: Colon
T2235090-ST	Biochain	5 Slides	EUR 572

Paraffin Tissue Section Panel - Human Adult Normal Tissue, Multi-tissue (8) IV
T8234601	Biochain	5 slides	EUR 242

Paraffin Tissue Section Panel - Human Adult Normal Tissue, Multi-tissue (8) V
T8234602	Biochain	5 slides	EUR 242

Paraffin Tissue Section Panel - Human Adult Normal Tissue, Multi-tissue (8) VI
T8234603	Biochain	5 slides	EUR 242

Paraffin Tissue Section Panel - Human Adult Normal Tissue, Multi-tissue (8) IX
T8234606	Biochain	5 slides	EUR 229

Paraffin Tissue Section Panel - Human Adult Normal Tissue, Multi-tissue (8) X
T8234607	Biochain	5 slides	EUR 229

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Skeletal Muscle
T2236171Dia	Biochain	5 slides	EUR 238

Paraffin Tissue Section Panel - Monkey (Rhesus) Normal Tissue, Multi-tissue III
T8534423	Biochain	5 slides	EUR 242

Paraffin Tissue Section - Dementia: Brain: Hippocampus
T2236052Dem	Biochain	5 slides	EUR 758

FitAmp Paraffin Tissue Section DNA Isolation Kit
P-1009	EpiGentek	EUR 702.06 EUR 239.80 EUR 454.30	100 Samples 50 Samples 100 Samples

Paraffin Tissue Section - Human Adult Normal: Brain
T2234035	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Colon
T2234090	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Heart
T2234122	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Liver
T2234149	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Ovary
T2234183	Biochain	5 slides	EUR 504

Paraffin Tissue Section - Human Adult Normal: Penis
T2234194	Biochain	5 slides	EUR 185

CancerSeq™ Paraffin Tissue Tumor Slides: Breast
T2235086-ST	Biochain	5 Slides	EUR 572

Paraffin Tissue Section - Human Adult Normal: Breast
T2234086	Biochain	5 slides	EUR 330

Paraffin Tissue Section - Human Adult Normal: Kidney
T2234142	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Rectum
T2234206	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Spleen
T2234246	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Testis
T2234260	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Throat
T2234263	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Tongue
T2234267	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Uterus
T2234274	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Vagina
T2234283	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Uterus Cervix Tumor
T2235275	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Adult Normal: Parotid
T2234190	Biochain	5 slides	EUR 185

Paraffin Tissue Section Panel - Human Adult Normal Tissue, Multi-tissue (8) VII
T8234604	Biochain	5 slides	EUR 242

Paraffin Tissue Section Panel - Human Adult Normal Tissue, Multi-tissue (8) VIII
T8234605	Biochain	5 slides	EUR 229

Paraffin Tissue Section Panel - Monkey (Cynomolgus) Normal Tissue, Multi-tissue II
T8534608-Cy	Biochain	5 slides	EUR 242

Paraffin Tissue Section - Depression: Brain: Hippocampus
T2236052Dep	Biochain	5 slides	EUR 758

Paraffin Tissue Section - Human Abdominal Tumor: Neuofibromatosis
T2235001-7	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Adult Normal: Adipose
T2234003	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Adrenal
T2234004	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Bladder
T2234010	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Trachea
T2234160	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Stomach
T2234248	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adipose Tumor: Lipoma
T2235003-1	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Angioma: Glomus Tumor
T2235011-2	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Bone Tumor: Chondroma
T2235023-2	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Adult Normal: Appendix
T2234006	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Pancreas
T2234188	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Placenta
T2234200	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Prostate
T2234201	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adrenal Tumor: Adenoma
T2235004-1	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Brain Tumor: Epndymoma
T2235035-6	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Testis Tumor: Seminoma
T2235260-3	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Dementia: Brain: Frontal Lobe
T2236051Dem	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Dementia: Brain: Parietal Lobe
T2236066Dem	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Parkinson's Disease: Brain: Pons
T2236071Par	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Adult Normal: Parathyroid
T2234189	Biochain	5 slides	EUR 629

Paraffin Tissue Section - Human Adult Normal: Esophagus
T2234106	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Diaphragm
T2234169	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Brain Tumor: Gliocytoma
T2235035-7	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Brain Tumor: Meningioma
T2235035-9	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Dementia: Brain: Temporal Lobe
T2236078Dem	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Ileum
T2236227Dia	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Adult Normal: Epididymis
T2234105	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Skin Tumor: Fibrosarcoma
T2235218-2	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Depression: Brain: Frontal Lobe
T2236051Dep	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Dementia: Brain: Occipital Lobe
T2236062Dem	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Pons
T2236071Alz	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Depression: Brain: Parietal Lobe
T2236066Dep	Biochain	5 slides	EUR 238

CancerSeq™ Plus Paraffin Tissue Tumor Section: Lung
T2235152-SC	Biochain	5 curls	EUR 779

Paraffin Tissue Section - Human Adult Normal: Gallbladder
T2234118	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Depression: Brain: Temporal Lobe
T2236078Dep	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Congenital heart disease: Heart
T2236122Hd-3	Biochain	5 slides	EUR 238

Paraffin Tissue Section - hypertension: Heart Atrium, left
T2236126Hd-2	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Jejunum
T2236230Dia	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Adult Normal: Brain: Pons
T2234071	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Adult Normal: Eye: Retina
T2234110	Biochain	5 slides	EUR 330

Paraffin Tissue Section - Human Adult Normal: Lymph Node
T2234161	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Parkinson's Disease: Brain: Amygdala
T2236036Par	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Parkinson's Disease: Brain: Thalamus
T2236079Par	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Adrenal Tumor: Myelolipoma
T2235004-3	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Bone Tumor: Chondrosarcoma
T2235023-3	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Breast Tumor: Fibroadenoma
T2235086-1	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Lung Tumor: Adenocarcinoma
T2235152-1	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Depression: Brain: Occipital Lobe
T2236062Dep	Biochain	5 slides	EUR 238

Paraffin Tissue Section - hypertension: Heart Atrium, right
T2236127Hd-2	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Adult Normal: Spinal Cord
T2234234	Biochain	5 slides	EUR 185

Paraffin Tissue Section - Human Kidney Tumor: Wilms' Tumor
T2235142-7	Biochain	5 slides	EUR 238

CancerSeq™ Paraffin Tissue Tumor Block: Skin Melanoma
T2235218A-SB	Biochain	1 Block	EUR 4014

Paraffin Tissue Section - Human Tumor Cell Line: MCF-7
T2255830	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Colon Tumor: Adenocarcinoma
T2235090-1	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Liver Tumor: Adenocarcinoma
T2235149-1	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain
T2236035Msc	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Duodenum
T2236101Dia	Biochain	5 slides	EUR 238

Paraffin Tissue Section - hypertension: Interventricular Septum
T2236130Hd-2	Biochain	5 slides	EUR 238

Paraffin Tissue Section Array - Human Adult Normal Tissue, Array I (64 Specimens)
T8234708-2	Biochain	2 slides	EUR 295

Paraffin Tissue Section Array - Human Adult Normal Tissue, Array I (64 Specimens)
T8234708-5	Biochain	5 slides	EUR 606

Paraffin Tissue Section - Human Adult Normal: Brain: Insula
T2234055	Biochain	5 slides	EUR 185

CancerSeq™ Plus Paraffin Tissue Tumor Sections: Breast
T2235086-SC	Biochain	5 curls	EUR 779

CancerSeq™ Paraffin Tissue Tumor Slides: Skin Melanoma
T2235218A-ST	Biochain	5 Slides	EUR 572

Paraffin Tissue Section - Parkinson's Disease: Brain: Cerebellum
T2236039Par	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Amygdala
T2236036Alz	Biochain	5 slides	EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Thalamus
T2236079Alz	Biochain	5 slides	EUR 238

Renal papillary renal cell carcinoma mRNA sequencing data obtained from The Cancer Genome Atlas revealed that chemokines, including CXCL1 / 2/3, CXCL8, MMP7 and CCL20, was positively correlated with the expression of B7-H4 gene. Furthermore, 59 clinical renal cell carcinoma tissue was collected and analyzed by immunohistochemical staining. The results showed a positive correlation with B7-H4 CCL20 and CXCL8, and validated degs identified in tumor cells.

786-O transfectants inoculated into non-obese diabetic / severe combined immunodeficiency mice and tumor growth were investigated. B7-H4 excess promoted tumor growth and anti-CXCL8 antibody administration reversed this effect