Identifying mismatch repair deficient colon cancer: near perfect concordance between immunohistochemistry and microsatellite instability testing in a large, population-based series

Identifying mismatch repair deficient colon cancer: near perfect concordance between immunohistochemistry and microsatellite instability testing in a large, population-based series

Objective: Establish a mismatch repair (MMR) status of colorectal cancer is essential to enable the detection of Lynch syndrome that underlie and inform prognosis and therapy. current testing usually involves either PCR-based microsatellite (MSI) testing or MMR protein immunohistochemistry (IHC). We aimed to compare the two approaches, a large population-based cohort of stage 2 and 3 cases of colon cancer in Northern Ireland.


Methods and results: Promega pentaplex Using this test, we determined the status of MSI’s four MMR IHC antibody panel. IHC applied to the tumor tissue microarray tumor samples in triplicate and scored manually. Of the 593 cases with available MSI and MMR IHC results, 136 (22.9%) were MSI-H and 135 (22.8%) displayed abnormal MMR IHC.

Concordance was very high, with 97.1% of MSI-H cases showed normal MMR IHC and 97.8% of cases with normal IHC showed MSI-H status. Under-representation of epithelial tumor cells in a sample of the tumor is very inflamed resulting in misclassification of some cases with microsatellite stable normal MMR IHC. MMR IHC revealed a rare case with unusual patterns of expression of MMR proteins, an unusual combination of loss of secondary clonal expression or loss of expression, is further illustrated by immunostaining repeated in all parts of the network.


Conclusions: PCR MSI and MMR IHC testing can be considered equally adept tests to establish the status of MMR / MSI, while aware of the potential pitfalls either method. Methodology selection may depend on the available services and expertise.


Anti-sclerostin monoclonal antibody romosozumab, treatment for osteoporosis, reduce the risk of vertebral fracture and clinical fracture. laser irradiation triggers a variety of effects, including bio-stimulation, which can induce beneficial effects of therapy and biological response. Initially, we performed in vivo experiments to clarify the mechanism better bone healing in bone laser ablated.

Here, we evaluated a comprehensive gene expression and sequence in the Er: YAG laser ablation, bur-drilled, and bones treated controls, and found the laser irradiation is pressed Sost (protein coding: sclerostin) expression in the bone, possibly through stimulation mechanotransducers. Surprisingly, the effect of laser bio-stimulation suppressed the expression of Sost in primary osteogenic cells.

Identifying mismatch repair deficient colon cancer: near perfect concordance between immunohistochemistry and microsatellite instability testing in a large, population-based series
Identifying mismatch repair deficient colon cancer: near perfect concordance between immunohistochemistry and microsatellite instability testing in a large, population-based series

SPARC is a key mediator of TGF-β-induced metastatic kidney cancer

Aberrant expression of transforming growth factor-β1 (TGF-β1) is associated with renal cell carcinoma (RCC) progression by inducing the cancer metastasis. However, downstream effector (s) in the TGF-β signaling pathway is not fully characterized. In this study, the height of secreted protein acidic and rich in cysteine ​​(SPARC) as regulated TGF-β genes in RCC were identified by applying the analysis of genes expressed differently and microarray analysis, we further confirmed these results in a few RCC cell lines.

Clinically, expression of both genes were positively correlated to the RCC patient specimens. Furthermore, increased expression of SPARC is found in all subtypes of RCC and RCC positively correlated with stage and grade. Instead, SPARC expression is inversely proportional to the overall and disease-free survival of patients with RCC, showing SPARC as a powerful prognostic marker of survival of RCC patients. SPARC knock down significantly inhibit invasion and metastasis of RCC cells both in vitro and in vivo.

p38 antibody

70R-51505 100 ul
EUR 268.00
Description: Purified Polyclonal p38 antibody

p38 antibody

70R-51506 100 ul
EUR 287.00
Description: Purified Polyclonal p38 antibody

p38 Antibody

48644-100ul 100ul
EUR 333.00

p38 Antibody

48644-50ul 50ul
EUR 239.00

p38 Antibody

35478-100ul 100ul
EUR 390.00

p38 Antibody

20-abx007541
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

p38 Antibody

20-abx133223
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

p38 Antibody

20-abx141038
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

p38 protein

E20-80078 20ug
EUR 408.00

p38 protein

E20-80079 20ug
EUR 408.00

anti-p38

YF-PA11120 50 ug
EUR 363.00
Description: Mouse polyclonal to p38

anti-p38

YF-PA11121 100 ug
EUR 403.00
Description: Rabbit polyclonal to p38

anti-p38

YF-PA23519 50 ul
EUR 334.00
Description: Mouse polyclonal to p38

anti-p38

YF-PA23520 50 ul
EUR 334.00
Description: Mouse polyclonal to p38

anti-p38

YF-PA23521 50 ul
EUR 334.00
Description: Mouse polyclonal to p38

LB (Lennox)

102 500 g
EUR 101.00

MM-102

B1582-2 2 mg
EUR 128.00
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

MM-102

B1582-20 20 mg
EUR 593.00
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

MM-102

B1582-5 5 mg
EUR 212.00
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

MM-102

B2364-25
EUR 588.00

MM-102

B2364-5
EUR 185.00

PPQ-102

B3504-10 10 mg
EUR 242.00

PPQ-102

B3504-5 5 mg
EUR 151.00

PPQ-102

B3504-50 50 mg
EUR 863.00

PM 102

B5517-1 1 mg
EUR 601.00

MM-102

HY-12220 10mg
EUR 298.00

IAXO-102

HY-125171 50mg
EUR 1944.00

PPQ-102

HY-14179 100mg
EUR 1221.00

BGB-102

HY-15732 10mg
EUR 6041.00

EL-102

HY-16187 10mM/1mL
EUR 376.00

LSZ-102

HY-111486 50mg
EUR 3321.00

SB-203580 p38 MAPK(p38 MAP kinase) Inhibitor

E1B1863 1mg
EUR 161.00

P38 Polyclonal Antibody

E-AB-36065-120uL 120uL
EUR 257.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
  • Purified by: Affinity purification
  • Background: MAPK14(mitogen-activated protein kinase 14) is also named as SAPK2A,p38MAPK,CSBP1,RK,p38,EXI
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat,Chicken P38 for WB,ELISA applications.

P38 Polyclonal Antibody

E-AB-36065-20uL 20uL
EUR 130.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
  • Purified by: Affinity purification
  • Background: MAPK14(mitogen-activated protein kinase 14) is also named as SAPK2A,p38MAPK,CSBP1,RK,p38,EXI
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat,Chicken P38 for WB,ELISA applications.

P38 Polyclonal Antibody

E-AB-36065-60uL 60uL
EUR 175.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
  • Purified by: Affinity purification
  • Background: MAPK14(mitogen-activated protein kinase 14) is also named as SAPK2A,p38MAPK,CSBP1,RK,p38,EXI
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat,Chicken P38 for WB,ELISA applications.

P38 Polyclonal Antibody

E-AB-36495-120uL 120uL
EUR 257.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
  • Purified by: Affinity purification
  • Background: MAPK14(mitogen-activated protein kinase 14) is also named as SAPK2A,p38MAPK,CSBP1,RK,p38,EXI
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat P38 for WB,ELISA applications.

P38 Polyclonal Antibody

E-AB-36495-20uL 20uL
EUR 130.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
  • Purified by: Affinity purification
  • Background: MAPK14(mitogen-activated protein kinase 14) is also named as SAPK2A,p38MAPK,CSBP1,RK,p38,EXI
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat P38 for WB,ELISA applications.

P38 Polyclonal Antibody

E-AB-36495-60uL 60uL
EUR 175.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
  • Purified by: Affinity purification
  • Background: MAPK14(mitogen-activated protein kinase 14) is also named as SAPK2A,p38MAPK,CSBP1,RK,p38,EXI
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat P38 for WB,ELISA applications.

P38 Polyclonal Antibody

E-AB-70001-120uL 120uL
EUR 253.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol.
  • Purified by: Affinity purification
  • Background: MAPK14(mitogen-activated protein kinase 14) is also named as SAPK2A,p38MAPK,CSBP1,RK,p38,EX
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat P38 for IHC applications.

P38 Polyclonal Antibody

E-AB-70001-200uL 200uL
EUR 400.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol.
  • Purified by: Affinity purification
  • Background: MAPK14(mitogen-activated protein kinase 14) is also named as SAPK2A,p38MAPK,CSBP1,RK,p38,EX
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat P38 for IHC applications.

P38 Polyclonal Antibody

E-AB-70001-60uL 60uL
EUR 182.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol.
  • Purified by: Affinity purification
  • Background: MAPK14(mitogen-activated protein kinase 14) is also named as SAPK2A,p38MAPK,CSBP1,RK,p38,EX
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat P38 for IHC applications.

P38 Polyclonal Antibody

E-AB-34076-120uL 120uL
EUR 257.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
  • Purified by: Affinity purification
  • Background: MAPK14(mitogen-activated protein kinase 14) is also named as SAPK2A,p38MAPK,CSBP1,RK,p38,EXI
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat P38 for WB,IHC-p,IF,ELISA applications.

P38 Polyclonal Antibody

E-AB-34076-20uL 20uL
EUR 130.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
  • Purified by: Affinity purification
  • Background: MAPK14(mitogen-activated protein kinase 14) is also named as SAPK2A,p38MAPK,CSBP1,RK,p38,EXI
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat P38 for WB,IHC-p,IF,ELISA applications.

P38 Polyclonal Antibody

E-AB-34076-60uL 60uL
EUR 175.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
  • Purified by: Affinity purification
  • Background: MAPK14(mitogen-activated protein kinase 14) is also named as SAPK2A,p38MAPK,CSBP1,RK,p38,EXI
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat P38 for WB,IHC-p,IF,ELISA applications.

p38 MAPK Antibody

abx236077-100ug 100 ug
EUR 481.00
  • Shipped within 5-12 working days.

p38 MAPK antibody

70R-33398 100 ug
EUR 327.00
Description: Rabbit polyclonal p38 MAPK antibody

p38 MAPK antibody

70R-33400 100 ug
EUR 327.00
Description: Rabbit polyclonal p38 MAPK antibody

P38 MAPK antibody

70R-34325 100 ug
EUR 327.00
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody

70R-34327 100 ug
EUR 327.00
Description: Rabbit polyclonal P38 MAPK antibody

p38 beta, Active

7763-100
EUR 4345.00

p38 beta, Active

7763-5
EUR 370.00

p38 MAPK Antibody

ABF6456 100 ug
EUR 438.00

Anti-p38 Antibody

A00176 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for p38 Antibody (MAPK14) detection.tested for WB in Human, Mouse, Rat.

p38 Polyclonal Antibody

ABP53838-003ml 0.03ml
EUR 158.00
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody

ABP53838-01ml 0.1ml
EUR 289.00
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody

ABP53838-02ml 0.2ml
EUR 414.00
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody

ABP53839-003ml 0.03ml
EUR 158.00
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Polyclonal Antibody

ABP53839-01ml 0.1ml
EUR 289.00
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Polyclonal Antibody

ABP53839-02ml 0.2ml
EUR 414.00
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Polyclonal Antibody

ABP57354-003ml 0.03ml
EUR 158.00
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human p38
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Polyclonal Antibody

ABP57354-01ml 0.1ml
EUR 289.00
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human p38
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Polyclonal Antibody

ABP57354-02ml 0.2ml
EUR 414.00
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human p38
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Polyclonal Antibody

ABP52112-003ml 0.03ml
EUR 158.00
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody

ABP52112-01ml 0.1ml
EUR 289.00
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody

ABP52112-02ml 0.2ml
EUR 414.00
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody

ABP52113-003ml 0.03ml
EUR 158.00
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody

ABP52113-01ml 0.1ml
EUR 289.00
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody

ABP52113-02ml 0.2ml
EUR 414.00
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 MAPK Antibody

49379-100ul 100ul
EUR 333.00

p38 MAPK Antibody

49379-50ul 50ul
EUR 239.00

p38 MAPK Antibody

20-abx012798
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

p38 MAPK Antibody

20-abx012875
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

Anti-p38 alpha

DB-1039 100 tests
EUR 474.00

Anti-p38 beta

DB-1040 100 tests
EUR 474.00

Anti-p38 gamma

DB-1041 100 tests
EUR 474.00

Anti-p38 delta

DB-1042 100 tests
EUR 474.00

Anti-p38-a

DB-161-0.05 50 μl
EUR 269.00

Anti-p38-a

DB-161-0.1 100 μl
EUR 422.00

Anti-p38-b

DB-162-0.05 50 μl
EUR 269.00

Anti-p38-b

DB-162-0.1 100 μl
EUR 422.00

Anti-p38-g

DB-163-0.05 50 μl
EUR 269.00

Anti-p38-g

DB-163-0.1 100 μl
EUR 422.00

Anti-p38-d

DB-164-0.05 50 μl
EUR 269.00

Anti-p38-d

DB-164-0.1 100 μl
EUR 422.00

Anti-p38 beta

DB1040 100 tests
EUR 474.00

Anti-p38 gamma

DB1041 100 tests
EUR 474.00

Anti-p38 delta

DB1042 100 tests
EUR 474.00

Anti-p38 alpha

DB1039 100 tests
EUR 474.00

p38 MAPK antibody

20R-1572 100 ug
EUR 705.00
Description: Rabbit polyclonal p38 MAPK antibody

P38 MAPK antibody

20R-2087 50 ug
EUR 281.00
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody

20R-2088 50 ug
EUR 281.00
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody

20R-2403 50 ug
EUR 281.00
Description: Rabbit polyclonal P38 MAPK antibody

p38 MAPK antibody

20R-2950 100 ul
EUR 393.00
Description: Rabbit polyclonal p38 MAPK antibody

p38 MAPK antibody

10R-8422 100 ul
EUR 393.00
Description: Mouse monoclonal p38 MAPK antibody

P38 delta protein

30R-2868 5 ug
EUR 503.00
Description: Purified recombinant Human P38 delta protein

p38 alpha protein

30R-2870 5 ug
EUR 503.00
Description: Purified recombinant Human p38 alpha protein

p38 beta protein

30R-2875 5 ug
EUR 503.00
Description: Purified recombinant Human p38 beta protein

p38 Polyclonal Antibody

41305-100ul 100ul
EUR 252.00

p38 Polyclonal Antibody

41305-50ul 50ul
EUR 187.00

p38 Polyclonal Antibody

41306-100ul 100ul
EUR 252.00

p38 Polyclonal Antibody

41306-50ul 50ul
EUR 187.00

p38 Blocking Peptide

20-abx061736
  • EUR 258.00
  • EUR 384.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

p38 Blocking Peptide

20-abx062080
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

p38 (pT180) Antibody

20-abx009863
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

P38 Polyclonal Antibody

E-AB-32459-120uL 120uL
EUR 257.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
  • Purified by: Affinity purification
  • Background: Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysacch
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat P38 for WB,IHC-p,ELISA applications.

P38 Polyclonal Antibody

E-AB-32459-20uL 20uL
EUR 130.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
  • Purified by: Affinity purification
  • Background: Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysacch
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat P38 for WB,IHC-p,ELISA applications.

P38 Polyclonal Antibody

E-AB-32459-60uL 60uL
EUR 175.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
  • Purified by: Affinity purification
  • Background: Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysacch
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat P38 for WB,IHC-p,ELISA applications.

P38 Polyclonal Antibody

E-AB-32460-120uL 120uL
EUR 257.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
  • Purified by: Affinity purification
  • Background: Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysacch
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat P38 for WB,IHC-p,IF,ELISA applications.

P38 Polyclonal Antibody

E-AB-32460-20uL 20uL
EUR 130.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
  • Purified by: Affinity purification
  • Background: Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysacch
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat P38 for WB,IHC-p,IF,ELISA applications.

P38 Polyclonal Antibody

E-AB-32460-60uL 60uL
EUR 175.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
  • Purified by: Affinity purification
  • Background: Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysacch
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat P38 for WB,IHC-p,IF,ELISA applications.

P38 Polyclonal Antibody

E-AB-32461-120uL 120uL
EUR 257.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
  • Purified by: Affinity purification
  • Background: Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysacch
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat P38 for WB,IHC-p,IF,ELISA applications.

P38 Polyclonal Antibody

E-AB-32461-20uL 20uL
EUR 130.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
  • Purified by: Affinity purification
  • Background: Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysacch
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat P38 for WB,IHC-p,IF,ELISA applications.

P38 Polyclonal Antibody

E-AB-32461-60uL 60uL
EUR 175.00
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
  • Purified by: Affinity purification
  • Background: Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysacch
  • Show more
Description: Rabbit antibody against Human,Mouse,Rat P38 for WB,IHC-p,IF,ELISA applications.

p38 (pY323) Antibody

20-abx133058
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

p38 Blocking Peptide

20-abx161932
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

p38 (pY182) Antibody

20-abx134951
  • EUR 384.00
  • EUR 606.00
  • EUR 230.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

p38 MAPK Antibody

AF6455 200ul
EUR 304.00
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.

p38 MAPK Antibody

AF6456 200ul
EUR 304.00
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.

p38 MAPK Antibody

AF6457 200ul
EUR 304.00
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.

Anti-p38 antibody

PAab06076 100 ug
EUR 355.00

p38 Polyclonal Antibody

ES3111-100ul 100ul
EUR 279.00
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody

ES3111-50ul 50ul
EUR 207.00
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody

ES3112-100ul 100ul
EUR 279.00
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES3112-50ul 50ul
EUR 207.00
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES4837-100ul 100ul
EUR 279.00
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES4837-50ul 50ul
EUR 207.00
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES4838-100ul 100ul
EUR 279.00
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody

ES4838-50ul 50ul
EUR 207.00
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody

ES8347-100ul 100ul
EUR 279.00
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat/Chicken. This antibody is tested and validated for WB, ELISA, WB, ELISA

p38 Polyclonal Antibody

ES8347-50ul 50ul
EUR 207.00
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat/Chicken. This antibody is tested and validated for WB, ELISA, WB, ELISA

anti-p38 MAPK

LF-PA0160 100 ul
EUR 334.00
Description: Rabbit polyclonal to p38 MAPK

anti- p38 antibody

FNab06076 100µg
EUR 505.25
  • Recommended dilution: WB: 1:200-1:2000
  • IF: 1:20-1:200
  • IHC: 1:50-1:500
  • Immunogen: mitogen-activated protein kinase 14
  • Uniprot ID: Q16539
  • Gene ID: 1432
  • Research Area: Immunology, Cardiovascular, Metabolism, Signal Transduction
Description: Antibody raised against p38

p38 alpha-MAPK14

RA15053 100 ug
EUR 526.00

Anti-p38 antibody

STJ97615 200 µl
EUR 197.00
Description: Rabbit polyclonal to p38.

Anti-P38 antibody

STJ98898 200 µl
EUR 197.00
Description: Mouse monoclonal to P38.

Anti-P38 antibody

STJ98899 200 µl
EUR 197.00
Description: Mouse monoclonal to P38.

Anti-p38 antibody

STJ94876 200 µl
EUR 197.00
Description: Rabbit polyclonal to p38.

Anti-p38 antibody

STJ94877 200 µl
EUR 197.00
Description: Rabbit polyclonal to p38.

Anti-p38 antibody

STJ94878 200 µl
EUR 197.00
Description: p38 is a protein encoded by the MAPK14 gene which is approximately 41,2 kDa. p38 is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, the IL-2 pathway, toll-like receptor signalling pathways, the VEGF signalling pathway and 4-1BB pathway. This protein falls under the MAP kinase family. It acts as an integration point for multiple biochemical signals, and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. p38 is expressed in the brain, heart, placenta, pancreas and skeletal muscle. Mutations in the MAPK14 gene may result in patellar tendinitis and lumbosacral lipoma. STJ94878 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of p38 protein.

Anti-p38 antibody

STJ94879 200 µl
EUR 197.00
Description: Rabbit polyclonal to p38.

Anti-p38 (3D5)

YF-MA12551 200 ul
EUR 363.00
Description: Mouse monoclonal to p38

Anti-p38 (1C9)

YF-MA12552 100 ug
EUR 363.00
Description: Mouse monoclonal to p38

anti-Crk p38

YF-PA11088 50 ul
EUR 363.00
Description: Mouse polyclonal to Crk p38

anti-Crk p38

YF-PA11089 50 ug
EUR 363.00
Description: Mouse polyclonal to Crk p38

anti-Crk p38

YF-PA11090 100 ug
EUR 403.00
Description: Rabbit polyclonal to Crk p38

anti-AIMP2/p38

YF-PA15507 50 ug
EUR 363.00
Description: Mouse polyclonal to AIMP2/p38

anti-Crk p38

YF-PA23509 50 ul
EUR 334.00
Description: Mouse polyclonal to Crk p38

MM-102 (TFA)

HY-12220A 10mM/1mL
EUR 263.00

BP-1-102

HY-100493 100mg
EUR 1345.00

Mouse P38 Mitogen-activated Protein Kinase (MAPK P38) CLIA Kit

abx197397-96tests 96 tests
EUR 825.00
  • Shipped within 5-12 working days.

Mouse MAPK P38(P38 Mitogen-activated Protein Kinase) ELISA Kit

EM1199 96T
EUR 524.10
  • Detection range: 1.25-80 ng/ml
  • Alias: MAPK P38
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.75 ng/ml

p38 MAPK antibody (Tyr322)

70R-33397 100 ug
EUR 327.00
Description: Rabbit polyclonal p38 MAPK antibody (Tyr322)

P38 MAPK antibody (Thr179)

70R-34324 100 ug
EUR 327.00
Description: Rabbit polyclonal P38 MAPK antibody (Thr179)

P38 MAPK antibody (Tyr182)

70R-34326 100 ug
EUR 327.00
Description: Rabbit polyclonal P38 MAPK antibody (Tyr182)

p38 MAPK antibody (Thr180)

70R-37313 100 ug
EUR 349.00
Description: Rabbit Polyclonal p38 MAPK antibody (Thr180)

p38 MAPK antibody (Tyr182)

70R-37314 100 ug
EUR 349.00
Description: Rabbit Polyclonal p38 MAPK antibody (Tyr182)

p38 MAPK Rabbit pAb

A5521-100ul 100 ul
EUR 308.00

p38 MAPK Rabbit pAb

A5521-200ul 200 ul
EUR 459.00

p38 MAPK Rabbit pAb

A5521-20ul 20 ul
EUR 183.00

p38 MAPK Rabbit pAb

A5521-50ul 50 ul
EUR 223.00

p38 MAP Kinase antibody

70R-11620 100 ug
EUR 418.00
Description: Rabbit polyclonal p38 MAP Kinase antibody

Phospho-p38 MAPK antibody

70R-11824 100 ug
EUR 525.00
Description: Rabbit polyclonal Phospho-p38 MAPK antibody

p38 MAPK Rabbit pAb

A8038-100ul 100 ul
EUR 308.00

p38 MAPK Rabbit pAb

A8038-200ul 200 ul
EUR 459.00

p38 MAPK Rabbit pAb

A8038-20ul 20 ul Ask for price

p38 MAPK Rabbit pAb

A8038-50ul 50 ul Ask for price

p38 MAPK Rabbit pAb

A10832-100ul 100 ul
EUR 384.00

p38 MAPK Rabbit pAb

A10832-200ul 200 ul
EUR 554.00

p38 MAPK Rabbit pAb

A10832-20ul 20 ul
EUR 183.00

p38 MAPK Rabbit pAb

A10832-50ul 50 ul
EUR 265.00

p38 MAPK Rabbit pAb

A11340-100ul 100 ul
EUR 308.00

p38 MAPK Rabbit pAb

A11340-200ul 200 ul
EUR 459.00

p38 MAPK Rabbit pAb

A11340-20ul 20 ul
EUR 183.00

p38 MAPK Rabbit pAb

A11340-50ul 50 ul
EUR 223.00

p38 MAPK Rabbit pAb

A14401-100ul 100 ul
EUR 308.00

Similarly, in vitro cell invasion could be reduced by using a specific monoclonal antibody. Mechanically, SPARC activate protein kinase B (AKT) pathway which leads to an increase in the expression of matrix metalloproteinase-2, which can facilitate the invasion of RCC. Overall, our data support the SPARC is an important role of TGF-β signaling networks that underlie the development of RCC and potential therapeutic targets and prognostic markers.