Tag: cla kids

August 16, 2020

The HIF target ATG9A is Essential for Epithelial Barrier Function and Tight Junction Biogenesis

intestinal epithelial cells (IECs) present in the metabolic state of low oxygen tension is called “physiological hypoxia.” An important factor in maintaining intestinal homeostasis is a transcription factor hypoxia-inducible factor (HIF), which is stabilized under hypoxic conditions and mediate the homeostatic response to low oxygen tension IEC. To identify the target HIF transcription in IEC, chromatin immunoprecipitation (CHIP) is performed in Caco-2 IECs using HIF-1α […]