Efemp1

Description: A polyclonal antibody against EFEMP1. Recognizes EFEMP1 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against EFEMP1. Recognizes EFEMP1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against EFEMP1. Recognizes EFEMP1 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human EFEMP1 (N-term). This antibody is tested and proven to work in the following applications:

Description: Description of target: EGF-containing fibulin-like extracellular matrix protein 1 is a protein that in humans is encoded by the EFEMP1 gene. This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

Description: Description of target: EGF-containing fibulin-like extracellular matrix protein 1 is a protein that in humans is encoded by the EFEMP1 gene. This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

Description: Description of target: Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.3 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.11"EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells."_x005F_x005F_x000D_Camaj P., Seeliger H., Ischenko I., Krebs S., Blum H., De Toni E.N., Faktorova D., Jauch K.W., Bruns C.J._x005F_x005F_x000D_Biol. Chem. 390:1293-1302(2009) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN EGFR ACTIVATION.Ref.13"Fibulin-3 is uniquely upregulated in malignant gliomas and promotes tumor cell motility and invasion."_x005F_x005F_x000D_Hu B., Thirtamara-Rajamani K.K., Sim H., Viapiano M.S._x005F_x005F_x000D_Mol. Cancer Res. 7:1756-1770(2009) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.14"Fibulin-3 negatively regulates chondrocyte differentiation."_x005F_x005F_x000D_Wakabayashi T., Matsumine A., Nakazora S., Hasegawa M., Iino T., Ota H., Sonoda H., Sudo A., Uchida A._x005F_x005F_x000D_Biochem. Biophys. Res. Commun. 391:1116-1121(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.64 ng/mL